Endothelin 1 (swine, human)

SKU: orb1706197

Description

Endothelin-1 (human, swine) is a key vasoconstrictor peptide produced by endothelial cells, signaling via ETA and ETB receptors. It is widely used in research models of hypertension, vascular remodeling, and endothelial dysfunction to study mechanisms of vasoconstriction, oxidative stress, and fibrosis in both in vitro and in vivo settings.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 117399-94-7
• MW: 2491.9
• Purity: 97.62% (May vary between batches)
• Formula: C₁₀₉H₁₅₉N₂₅O₃₂S₅
• SMILES: C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H]([C@H](C)C)NC(=O)[C@]5(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CSSC2)(CSSC5)[H])[H])=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=6C=7C(NC6)=CC=CC7
• Target: Reactive Oxygen Species
• Solubility: H2O:50 mg/mL (20.07 mM);DMSO:≥ 40 mg/mL

Bioactivity

• In Vitro:
  Endothelin-1 (ET-1), a potent endogenous vasoconstrictor primarily secreted by endothelial cells, operates via ETA and ETB receptors. Beyond its vasoconstrictive effect, ET-1 contributes to vascular cell fibrosis and prompts the generation of reactive oxygen species. Additionally, ET-1 is implicated in proinflammatory mechanisms by elevating superoxide anion output and cytokine release.

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endothelin 1 (swine, human), Endothelin 1, ETA and ETB

Compound Identifiers

PubChem CID

16168476