Emedastine

SKU: orb1303482

Description

Emedastine is a selective H1 receptor antagonist that reversibly blocks histamine, inhibiting mast cell mediator release and calcium mobilization. It is used in research on allergic conjunctivitis, studying histamine-induced vascular permeability in vivo and mast cell/basophil activation in vitro.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87233-61-2
• MW: 302.41
• Purity: 97.76% (May vary between batches)
• Formula: C₁₇H₂₆N₄O
• SMILES: CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1
• Target: Histamine Receptor
• Solubility: DMSO:50 mg/mL (165.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM)

Bioactivity

• Target IC50:
  H2 receptor:49067 nM (Ki)|H3 receptor:12430 nM (Ki)|H1 receptor:1.3 nM(Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

allergic, antiallergic, diseases, conjunctivitis, benzimidazole, inhibit, LY 188695, LY188695, LY-188695, orally, Emedastine, Emadine, H1 receptor, Inhibitor, HistamineReceptor, Histamine Receptor, rhinitis, skin

Compound Identifiers

PubChem CID

3219