Elobixibat

SKU: orb1707339

Description

Elobixibat (A 3309) is a potent and selective ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.13 nM (mouse), 0.53 nM (human), and 5.8 nM (canine). This investigational compound is utilized in preclinical and clinical research for studying chronic idiopathic constipation and related gastrointestinal motility disorders.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 439087-18-0
• MW: 695.89
• Purity: 98.03% (May vary between batches)
• Formula: C₃₆H₄₅N₃O₇S₂
• SMILES: CCCCC1(CCCC)CN(c2ccccc2)c2cc(SC)c(OCC(=O)N[C@@H](C(=O)NCC(O)=O)c3ccccc3)cc2S(=O)(=O)C1
• Target: Interleukin,Others,TNF,ASBT
• Solubility: DMSO:225 mg/mL (323.33 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.19 mM)

Bioactivity

• Target IC50:
  IBAT (human):0.53 nM|IBAT (canine):5.8 nM|IBAT (mouse):0.13 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mouse IBAT, Elobixibat, IBAT, human IBAT, A 3309, A3309, A-3309, AZD 7806, AZD7806, AZD-7806, canine IBAT

Compound Identifiers

PubChem CID

9939892