Eliprodil

SKU: orb1226832

Description

Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM); inhibits [3H]norepinephrine release from cortical and hippocampal slices but enhances the basal efflux of endogenous and tritiated dopamine from striatal slices, also blocks the uptake of [3H]dopamine into striatal synaptosomes with IC50 of 1.5 uM; reduces the volume of infarction in models of focal cerebral ischemia.Stroke Phase 3 Discontinued.

Key Properties

• CAS Number: 119431-25-3
• MW: 347.8541
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₃ClFNO
• SMILES: OC(C1=CC=C(Cl)C=C1)CN2CCC(CC3=CC=C(F)C=C3)CC2
• Target: iGluR
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SL-820715

Quick Database Links

Gene Symbol

iGluR