HR-19011

SKU: orb1686373

Description

HR-19011 (Compound 40) is a small molecule inducer of eIF2α phosphorylation, leading to increased expression of downstream proteins ATF4 and CHOP. It exhibits anti-proliferative activity in the low micromolar range against K562 leukemia cells and PBMCs in vitro, making it a useful research tool for studying the integrated stress response and cellular apoptosis pathways.

Research Area

Cell Biology

Key Properties

• CAS Number: 2851820-52-3
• MW: 523.43
• Purity: 99.89% (May vary between batches)
• Formula: C₂₅H₁₉F₆N₃O₃
• SMILES: N(C1=C(N[C@H]2CC[C@H](OC3=CC=C(C(F)(F)F)C=C3)CC2)C(=O)C1=O)C4=CC(C(F)(F)F)=CC(C#N)=C4
• Target: PERK
• Solubility: DMSO:20 mg/mL (38.21 mM)

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HR19011, EIF2α activator 1

Compound Identifiers

PubChem CID

164517084