EHop-016

SKU: orb1226405

Description

EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.

Key Properties

• CAS Number: 1380432-32-5
• MW: 430.55
• Purity: >98% (HPLC)
• Formula: C₂₅H₃₀N₆O
• SMILES: CCN1C2=C(C3=C1C=CC=C3)C=C(NC4=NC(NCCCN5CCOCC5)=NC=C4)C=C2
• Target: Rho
• Solubility: DMSO: 86 mg/mL (199.74 mM)

Bioactivity

• In Vivo:
  Animal model: Female athymic nu/nu mice (4-5 weeks old) injected with GFP-MDA-MB-435 cells. Dosage: 10 mg/kg, 25 mg/kg. Administration: Intraperitoneal injection; 3 times a week; for 55 days. Result: Significantly reduced mammary fat pad tumor growth, metastasis, and angiogenesis.
• In Vitro:
  Western blot analysis. Cell line: MDA-MB-435 cells. Concentration: 1 μM, 2 μM, 4 μM, 5 μM, 10 μM. Incubation time: 24 hours. Result: The activity Rac3 was inhibited by 58%.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EHop016 | EHop-016 | EHop 016 | EHOP016

Quick Database Links

Gene Symbol

Rho