EGFR-IN-9

SKU: orb1709789

Description

EGFR-IN-9 is a potent and selective epidermal growth factor receptor (EGFR) kinase inhibitor, demonstrating IC50 values of 7 nM and 28 nM against wild-type and L858R/T790M mutant EGFR, respectively. This compound exhibits antitumor activity and is a valuable chemical probe for oncology research, supporting investigations into EGFR-driven cancers in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1226549-39-8
• MW: 476.53
• Purity: 99.80% (May vary between batches)
• Formula: C₂₉H₂₄N₄O₃
• SMILES: OC[C@@H](Nc1ncnc2oc(c(-c3cccc(NC(=O)C=C)c3)c12)-c1ccccc1)c1ccccc1
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.93 mM);DMSO:90 mg/mL (188.87 mM)

Bioactivity

• Target IC50:
  EGFR (WT):7 nM|EGFR (L858R/T790M):28 nM
• In Vitro:
  EGFR-IN-9 shows antiproliferative activity in HCC827 lung cancer cell line with an IC50 of 8 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGFR (L858R/T790M), EGFR (wt), EGFR IN 9, EGFR(WT), EGFRL858R/T790M, EGFRIN9, EGFR-IN-9

Compound Identifiers

PubChem CID

46212970