EGFR-IN-5

SKU: orb1709790

Description

EGFR-IN-5 is a potent and selective EGFR inhibitor with IC50 values of 10.4 nM (wild-type), 1.1 nM (L858R), 34 nM (L858R/T790M), and 7.2 nM (L858R/T790M/C797S). This compound is a valuable research tool for studying EGFR-driven cancers in biochemical and cellular assays, aiding in the investigation of resistance mechanisms and therapeutic strategies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2225887-26-1
• MW: 571.69
• Purity: 98.17% (May vary between batches)
• Formula: C₃₁H₃₈FN₉O
• SMILES: N(C=1N=C(C2=C(N1)C=NC(NC3=CC=C(C=N3)N4CCC(N(C)C)CC4)=C2)N5CCC(CO)CC5)C6=CC=C(F)C=C6
• Target: EGFR
• Solubility: DMSO:120 mg/mL (209.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7 mM)

Bioactivity

• Target IC50:
  EGFR:10.4 nM|EGFR (L858R/T790M):34 nM|EGFR (L858R/T790M/C797S):7.2 nM|EGFR (L858R):1.1 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HER1, Inhibitor, ErbB-1, Epidermal growth factor receptor, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (L858R/T790M/C797S), EGFR IN 5, EGFRIN5, EGFR-IN-5, EGFRL858R/T790M, EGFRL858R/T790M/C797S, EGFRL858R, inhibit

Compound Identifiers

PubChem CID

134817166