EGFR-IN-117

SKU: orb2646063

Description

EGFR-IN-117 (Compound 8h) is a potent and selective EGFR inhibitor effective against multiple resistant mutations, including L858R/T790M/C797S. It demonstrates nanomolar IC50 values in cell lines like H1975 and PC-9 and has shown in vivo anti-tumor efficacy in mouse models, supporting its use in oncology research targeting EGFR-driven cancers.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3035639-05-2
• MW: 572.52
• Formula: C₂₅H₃₀BrN₇O₂S
• SMILES: O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)N4CCN(C)CCC4)C5CC5
• Target: Apoptosis,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171904685