Ecopipam hydrochloride

SKU: orb3027229

Description

Ecopipam (SCH 39166) hydrochloride is a highly potent, selective, and orally active antagonist of dopamine D1/D5 receptors. It exhibits impressive binding affinities, with Ki values of 1.2 nM and 2.0 nM for D1 and D5 receptors, respectively. Ecopipam hydrochloride demonstrates remarkable selectivity, displaying over 40-fold selectivity compared to D2, D4, 5-HT, and α2a receptors, with Ki values of 0.98 μM, 5.52 μM, 0.08 μM, and 0.73 μM, respectively. Its application extends to various areas of research, including schizophrenia, cocaine addiction, and obesity.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 190133-94-9
• MW: 350.28
• Formula: C₁₉H₂₁Cl₂NO
• SMILES: Cl.[H][C@]12CCc3ccccc3[C@]1([H])c1cc(O)c(Cl)cc1CCN2C
• Target: 5-HT Receptor,Dopamine Receptor,Adrenergic Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor,Dopamine Receptor,Adrenergic Receptor