Econazole nitrate

SKU: orb1310609

Description

Econazole nitrate (Spectazole) is an antifungal agent of the imidazole class used in research. It is applied in vitro to study mechanisms of fungal growth inhibition and has been utilized in animal models for investigating topical antifungal treatments.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 24169-02-6
• MW: 444.70
• Purity: >99.99%
• Formula: C₁₈H₁₅Cl₃N₂O·HNO₃
• SMILES: O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
• Target: Antifungal,Antifection,Antibacterial,Antibiotic
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (112.44 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM);Ethanol:5 mg/mL (11.24 mM)

Bioactivity

• In Vitro:
  Econazole nitrate is an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). Econazole nitrate inhibits the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method and colony forming assay. Econazole nitrate results in typical characteristics of apoptosis including the morphological changes and DNA fragmentation in MCF-7 cells. Econazole nitrate results in the decrease expression of procaspase-3, procaspase-9 and bcl-2. Econazole inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). Econazole produces an essentially complete inhibition of the TRPM2-mediated current. Econazole (25-50 mM) partially inhibits capacitative Ca2+ entry induced by cyclopiazonic acid, another endoplasmic reticulum Ca2+ pump inhibitor. Econazole induces Ca2+ influx via two separate pathways: one is sensitive to La3+, the other is not. Econazole reversibly inhibits (Bu)(2)cAMP-stimulated progesterone production in a dose- and time-dependent manner in MA-10 cells without affecting total protein synthesis or P450(scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme expression or activity. Econazole is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. Econazole (5-20 mM) arrests human colon cancer cells at the G0/G1 phase of the cell cycle. Econazole induces COLO 205 cells apoptosis evidenced by ladder formation in DNA fragmentation assay and sub-G1 peak.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fungal, Econazole nitrate, Econazole Nitrate, Econazole, inhibit, Inhibitor, NSC 243115, NSC243115, NSC-243115, 14-α Demethylase, Bacterial, Antibiotic

Compound Identifiers

PubChem CID

68589