Eclitasertib

SKU: orb1297937

Description

Eclitasertib is a potent small molecule RIPK1 inhibitor with an IC50 below 1 µM. It is a valuable research tool for studying necroptosis and inflammation in cellular and animal models of neurodegenerative and inflammatory diseases.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2125450-76-0
• MW: 378.38
• Purity: 99.85%
• Formula: C₁₉H₁₈N₆O₃
• SMILES: CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
• Target: RIP kinase
• Solubility: DMSO:125 mg/mL (330.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.57 mM)

Bioactivity

• Target IC50:
  RIPK1:<1 µΜ

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNL 758, DNL758, DNL-758, inhibit, Eclitasertib, Inhibitor, Receptor-interacting protein kinases, SAR 443122, SAR443122, SAR-443122, RIP kinase, RIPK, RIPK1, RIPkinase

Compound Identifiers

PubChem CID

130298939