Ecamsule

SKU: orb1217460

Description

Ecamsule is a benzylidene camphor derivative, many of which are known for their excellent photostability. Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 92761-26-7
• MW: 562.7
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₄O₈S₂
• SMILES: CC1(C2CCC1(C(=O)C2=CC3=CC=C(C=C3)C=C4C5CCC(C4=O)(C5(C)C)CS(=O)(=O)O)CS(=O)(=O)O)C
• Target: Others
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment.. Ecamsule counteractes UV and AAPH induced ROS-formation.. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%.. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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