EBI-2511

SKU: orb1308353

Description

EBI-2511

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2098546-05-3
• MW: 576.77
• Purity: 99.01%
• Formula: C₃₄H₄₈N₄O₄
• SMILES: CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC)C1CCN(CC1)C(C)C
• Target: Histone Methyltransferase
• Solubility: DMSO:5 mg/mL (8.67 mM)

Bioactivity

• Target IC50:
  EZH2:6 nM (in cell)
• In Vivo:
  EBI-2511 demonstrates dose-dependent tumor growth inhibition, with tumor size reductions of 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg). No significant changes in body weights are observed across all treatment groups. At the same dosage, EBI-2511 shows superior anti-tumor efficacy compared to EPZ-6438 (P<0.01) .
• In Vitro:
  EBI-2511 obviously decreases cellular H3K27me3 levels in a dose-dependent manner (an approximate IC50: 8 nM) and it is 3-fold more potent than EPZ-6438. In addition to Pfeffier cell line, EBI-2511 was shown active against WSU-DLCL2 ( IC50: 55 nM) .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Histone Methyltransferase, HistoneMethyltransferase, EBI2511, EBI-2511, EBI 2511, EZH2, inhibit

Compound Identifiers

PubChem CID

133081962