EBE-A22

SKU: orb1223177

Description

EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.

Key Properties

• CAS Number: 229476-53-3
• MW: 374.23
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₆BrN₃O₂
• SMILES: CN(c1cc(ccc1)Br)c1ncnc2cc(c(cc12)OC)OC
• Target: FGFR
• Solubility: DMSO : 50 mg/mL 133.61 mM; H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EBE-A22 | EBE A22 | EBEA22

Quick Database Links

Gene Symbol

FGFR