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E3 ligase Ligand 23

SKU: orb1297865

Description

Ligand 23 is a cereblon E3 ligase-binding molecule that induces the ubiquitin-proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). This mechanism of action makes it a valuable chemical probe for studying immunology and oncology in both cellular and animal models of disease.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number444287-56-3
MW363.37
Purity98.49% (May vary between batches)
FormulaC20H17N3O4
SMILESN(CC1=CC=CC=C1)C2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2
TargetLigand for E3 Ligase
SolubilityDMSO:55 mg/mL (151.36 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E3 ligase-recruiting Moiety, E3 ligase Ligand 23, E-3 ligase Ligand 23, Cereblon, Aiolos, Inhibitor, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, inhibit, Ikaros, ubiquitin proteasome

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 80.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 150.00
25 mg
$ 260.00
50 mg
$ 400.00
100 mg
$ 550.00
200 mg
$ 730.00
DispatchUsually dispatched within 5-10 working days
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