E-64

SKU: orb1301130

Description

E-64

Research Area

Cell Biology

Key Properties

• CAS Number: 66701-25-5
• MW: 357.41
• Purity: >98%
• Formula: C₁₅H₂₇N₅O₅
• SMILES: CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCN=C(N)N
• Target: Protease
• Solubility: Soluble in a 1:1 mixture of Ethanol and water (up to 20 mg/ml)

Bioactivity

• Target IC50:
  Cysteine protease:9 nM
• In Vivo:
  E-64 induces a marked decrease in the number of spontaneous metastasis in M5076 tumor bearing mice, while has no effect on the formation of experimental metastasis. E-64 also shows antiparasitic activity against Giardia lamblia excystation in infected mice.
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• In Vitro:
  E-64 rapidly inhibits the activities of the cysteine proteinases cathepsins B, H and L and papain, while has no effect on the serine proteinases or the metalloproteinases. E-64, as a specific inhibitor os cysteine proteases, effectively blocks in vitro ovarian cancer cell invasion. In addition, E-64 also shows antiparasitic activity against Giardia lamblia excystation in vitro. E-64 improves the preimplantation development of bovine somatic cell nuclear transfer embryos, which indicates another important implication of E-64.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proteinase inhibitor E 64, Proteinase inhibitor E64, Proteinase inhibitor E-64, inhibit, Inhibitor, Cathepsin, Autophagy, Bacterial, CysteineProtease, Cysteine protease, Cysteine Protease, E64, E-64, E 64

Compound Identifiers

PubChem CID

4641099