E-64

SKU: orb1301130

Description

E-64

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 66701-25-5
• MW: 357.41
• Purity: 99.95%
• Formula: C₁₅H₂₇N₅O₅
• SMILES: CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCN=C(N)N
• Target: Autophagy,Antibacterial,Cysteine Protease
• Solubility: H2O:9 mg/mL (25.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.6 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:59.38 mg/mL (166.14 mM)

Bioactivity

• Target IC50:
  Cysteine protease:9 nM
• In Vivo:
  E-64 induces a marked decrease in the number of spontaneous metastasis in M5076 tumor bearing mice, while has no effect on the formation of experimental metastasis. E-64 also shows antiparasitic activity against Giardia lamblia excystation in infected mice.
• In Vitro:
  E-64 rapidly inhibits the activities of the cysteine proteinases cathepsins B, H and L and papain, while has no effect on the serine proteinases or the metalloproteinases. E-64, as a specific inhibitor os cysteine proteases, effectively blocks in vitro ovarian cancer cell invasion. In addition, E-64 also shows antiparasitic activity against Giardia lamblia excystation in vitro. E-64 improves the preimplantation development of bovine somatic cell nuclear transfer embryos, which indicates another important implication of E-64.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proteinase inhibitor E 64, Proteinase inhibitor E64, Proteinase inhibitor E-64, inhibit, Inhibitor, Cathepsin, Autophagy, Bacterial, CysteineProtease, Cysteine protease, Cysteine Protease, E64, E-64, E 64

Compound Identifiers

PubChem CID

4641099