Dyrk1A-IN-11

SKU: orb2695423

Description

Dyrk1A-IN-11 (compound 166) is a potent small molecule inhibitor of DYRK1A (EC50 = 0.0021 µM) and also suppresses Tau phosphorylation at Thr212 (EC50 = 0.0361 µM). This compound is a valuable research tool for investigating DYRK1A and tau-related mechanisms in neurodegenerative disease models, both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3058626-26-6
• MW: 522.47
• Formula: C₂₃H₂₃F₅N₈O
• SMILES: FC=1C(=C2N(C1)N=C(N[C@H]3C(F)(F)CN(CC3)C4COC4)N=C2)C=5N=C6C(=CC5)N=C(C)N6CC(F)F
• Target: DYRK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172361737