DUB-IN-3

SKU: orb1309733

Description

DUB-IN-3 is a potent and selective small molecule inhibitor of deubiquitinase (DUB) enzymes, with an IC50 of 0.56 µM against USP8. It is a valuable research tool for investigating DUB function in cellular processes and disease models, applicable in both in vitro biochemical and cell-based assays.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 924296-17-3
• MW: 287.28
• Purity: 99.34% (May vary between batches)
• Formula: C₁₆H₉N₅O
• SMILES: C=CCO\N=C1/c2ccccc2-c2nc(C#N)c(nc12)C#N
• Target: DUB
• Solubility: DMSO:3.33 mg/mL (11.59 mM)

Bioactivity

• Target IC50:
  USP7:>100 μM|USP8:0.56 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deubiquitinase, DUBs, DUBIN3, DUB-IN-3, DUB IN 3, Inhibitor, inhibit, USP8

Compound Identifiers

PubChem CID

16065489