DSM421

SKU: orb1700693

Description

DSM421

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 2011769-21-2
• MW: 358.27
• Purity: 99.93%
• Formula: C₁₄H₁₁F₅N₆
• SMILES: N(C=1N2C(=NC(C(C)(F)F)=N2)N=C(C)C1)C=3C=CC(C(F)(F)F)=NC3
• Target: Parasite,Dehydrogenase
• Solubility: DMSO:10 mg/mL (27.91 mM)

Bioactivity

• In Vivo:
  DSM421, a dihydroorotate dehydrogenase inhibitor, was in preclinical development as a potential treatment option for malaria. When tested in a core battery of safety pharmacology assays, DSM421 did not produce any effects at oral doses up to 750 mg/kg in an Irwin test in rats, but a respiratory study in rats using head-out plethysmography resulted in substantial changes in respiratory function as well as moribundity and mortality at that and lower doses.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHODH, DSM 421, DSM421, DSM-421

Compound Identifiers

PubChem CID

122552662