DS-1971a

SKU: orb1297949

Description

DS-1971a is a potent and selective small molecule inhibitor of the voltage-gated sodium channel NaV1.7. It demonstrates a favorable safety profile and has shown analgesic efficacy in preclinical models, making it a valuable tool for pain research in both in vitro and in vivo studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1450595-86-4
• MW: 465.93
• Purity: 99.77% (May vary between batches)
• Formula: C₂₀H₂₁ClFN₅O₃S
• SMILES: Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
• Target: Sodium Channel
• Solubility: DMSO:100 mg/mL (214.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.58 mM)

Bioactivity

• Target IC50:
  Nav1.7 (mouse):59.4 nM|Nav1.7 (human):22.8 nM
• In Vivo:
  DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg.
• In Vitro:
  DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DS 1971a, DS1971a, DS-1971a, inhibit, Na+ channels, Na channels, Nav1.7 channel, Inhibitor, hyperalgesia, hypersensitivity, mechanical, thermal, toxicity, Sodium Channel, SodiumChannel

Compound Identifiers

PubChem CID

71711862