DRF-1042

SKU: orb1707360

Description

DRF-1042

Research Area

Molecular Biology

Key Properties

• CAS Number: 200619-13-2
• MW: 408.4
• Purity: 97.00% (May vary between batches)
• Formula: C₂₂H₂₀N₂O₆
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3C(OCCO)n1c2=O
• Target: ADC Cytotoxin,Topoisomerase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.9 mM);DMSO:30 mg/mL (73.46 mM)

Bioactivity

• In Vivo:
  DRF-1042 treatment showed adverse myelosuppressive effects in clone formation assays against mouse, canine and human bone marrow cells. This supports the possibility of extending the dosing schedule in experimental and clinical studies .
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• In Vitro:
  DRF-1042 displays excellent endostatin stability and good in vitro anticancer activity. It confronts a range of human cancer cell lines including multi-drug resistant (MDR) phenotypes .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA topoisomerase I, DRF 1042, DRF1042, DRF-1042, Topo

Compound Identifiers

PubChem CID

23631031