DOPEXAMINE

SKU: orb1298742

Description

Dopexamine is a synthetic catecholamine that acts as an agonist at dopamine D1 and β2-adrenergic receptors. It is utilized in research to study cardiovascular pharmacology, particularly in models of heart failure and shock, investigating its inotropic and vasodilatory effects in both in vitro and in vivo experimental systems.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 86197-47-9
• MW: 356.5
• Purity: 99.42% (May vary between batches)
• Formula: C₂₂H₃₂N₂O₂
• SMILES: C(CNCCCCCCNCCC1=CC=CC=C1)C2=CC(O)=C(O)C=C2
• Target: Adrenergic Receptor,Dopamine Receptor
• Solubility: DMSO:55 mg/mL (154.28 mM)

Bioactivity

• In Vivo:
  Dopexamine hydrochloride has interesting vasodilator properties, with marked intrinsic agonist activity at beta-2 adrenoreceptors and a lesser agonist activity at dopaminergic receptors (DA1 and DA2). Dopexamine hydrochloride is responsible for an inhibition of neuronal re-uptake of catecholamines (uptake-1), producing an indirect stimulation of cardiac beta 1-receptors. Dopexamine hydrochloride improves cardiac performance by a marked vasodilation and a mild inotropic activity. The specific activity at dopaminergic receptors increases cerebral, myocardial, splanchnic and renal blood flows. These haemodynamic effects are associated with an increase in diuresis and natriuresis. These benefits are achieved without side effects such as an increased myocardial oxygen consumption, although induced tachycardia may be responsible for chest pain/anginae pain in patients with ischaemic heart disease.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DOPEXAMINE, DopamineReceptor, Dopamine, Dopamine Receptor

Compound Identifiers

PubChem CID

55483