Dofetilide

SKU: orb1226902

Description

Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.(In Vitro):Dofetilide (3~100 μg/kg; i.v.) increases repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.Dofetilide is metabolized by CYP3A4 to a mixture of inactive polar metabolites that are then excreted by the kidney.

Key Properties

• CAS Number: 115256-11-6
• MW: 441.56
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₇N₃O₅S₂
• SMILES: CS(=O)(NC1=CC=C(OCCN(CCC2=CC=C(NS(=O)(C)=O)C=C2)C)C=C1)=O
• Target: Potassium Channel
• Solubility: DMSO:88 mg/mL warmed (199.29 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Animal model: Adult beagle dogs (13-15 kg). Dosage: 3~100 μg/kg. Administration: I. v. Result: Increased repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tikosyn | UK 68789

Quick Database Links

Gene Symbol

Potassium Channel