Divalproex Sodium

SKU: orb1300737

Description

Divalproex sodium is a histone deacetylase (HDAC) inhibitor and anticonvulsant agent that elevates brain GABA levels by inhibiting its catabolism and reuptake, while also blocking voltage-sensitive sodium channels. It is widely used in neuroscience research for studying epilepsy, bipolar disorder, and neuropathic pain mechanisms in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 76584-70-8
• MW: 310.41
• Purity: 99.87% (May vary between batches)
• Formula: C₈H₁₆O₂·C₈H₁₅O₂·Na
• SMILES: [Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O
• Target: HIV Protease,Gamma-secretase,GABA Receptor,Mitophagy,Apoptosis,Endogenous Metabolite,Autophagy,HDAC
• Solubility: Ethanol:58 mg/mL (186.85 mM);H2O:57 mg/mL (183.63 mM);DMSO:75 mg/mL (241.62 mM)

Bioactivity

• Target IC50:
  HDAC:0.5-2 mM|HDAC1:400 μM
• In Vivo:
  Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas 50 mg/kg has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.
• In Vitro:
  Divalproex sodium enhances apoptosis, IM-induced cell growth inhibition and cell cycle arrest in K562-G and K562-S cells. It enhances the inhibitory effects of IM on SIRT1 expression in K562-G and K562-S cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone deacetylases, HIV, Inhibitor, hepatic fat accumulation, headaches, HDAC, Human immunodeficiency virus, GABAReceptor, GABA Receptor, Endogenous Metabolite, epilepsy, Epival, Mitochondrial Autophagy, Mitophagy, migraine, inhibit, Notch, Notch1, 2-Propylpentanoic Acid (sodium)(2:1), anticonvulsant, anticancer, Apoptosis, Autophagy, bipolar disorder, degradation, Divalproex Sodium, proteasomal, small cell lung cancer, SCLC, Valproate semisodium, Valproic acid (sodium)(2:1), VPA (sodium)(2:1)

Compound Identifiers

PubChem CID

23663956