Disodium monofluorophosphate

SKU: orb1710686

Description

Disodium monofluorophosphate (NSC248) acts as a competitive inhibitor of pyruvate kinase and alkaline phosphatase, while also serving as an irreversible inhibitor of phosphorylase phosphatase. This small molecule is utilized in biochemical research to study metabolic regulation and enzyme kinetics in both in vitro and cell-based experimental systems.

Research Area

Metabolism Research

Key Properties

• CAS Number: 10163-15-2
• MW: 143.95
• Formula: FNa₂O₃P
• SMILES: O=P([O-])(F)[O-].[Na+].[Na+]
• Target: PKM,Phosphorylase,Phosphatase
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Phosphorylase phosphatase:0.5 mM(Ki)|Pyruvate kinase:3.4 mM(Ki)|ALP:69 μM(Ki)
• In Vivo:
  Monofluorophosphate showed potent activity against bone immobilization in vivo. Drinking water containing 50 ppm Monofluorophosphate showed a significant increase in bone disease in mobile and immobile tibia (1.48 and 0.98 mM, respectively, and 0.79 and 0.40 mM, respectively) as compared to the fluoride-free water group. Monofluorophosphate increased the rate of bone mineralization and counteracted immobilization-induced decreases in bone thickness, ash content, and specific gravity without altering the Ca/P ratio of ash.Monofluorophosphate had no effect on the specific gravity of immobilized and immobilized tibiae in rats.
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• In Vitro:
  Monofluorophosphate showed potent activity against bone immobilization in vivo. Drinking water containing 50 ppm Monofluorophosphate showed a significant increase in bone disease in mobile and immobile tibia (1.48 and 0.98 mM, respectively, and 0.79 and 0.40 mM, respectively) as compared to the fluoride-free water group. Monofluorophosphate increased the rate of bone mineralization and counteracted immobilization-induced decreases in bone thickness, ash content, and specific gravity without altering the Ca/P ratio of ash.Monofluorophosphate had no effect on the specific gravity of immobilized and immobilized tibiae in rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

alkaline phosphatase, Disodium monofluorophosphate, NSC 248, NSC248, NSC-248, pyruvate kinase, phosphorylase phosphatase

Compound Identifiers

PubChem CID

24266