DiMNF

SKU: orb1704573

Description

DiMNF (3',4'-Dimethoxy-αNF) is a potent and selective aryl hydrocarbon receptor (AHR) ligand. It exhibits anti-inflammatory properties by inhibiting cytokine-induced complement factor gene expression, making it a valuable tool for studying AHR-mediated immunology in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 14756-24-2
• MW: 332.35
• Purity: 97.60% (May vary between batches)
• Formula: C₂₁H₁₆O₄
• SMILES: O=C1C=C(OC2=C1C=CC=3C=CC=CC32)C=4C=CC(OC)=C(OC)C4
• Target: AhR,Aryl Hydrocarbon Receptor
• Solubility: DMSO:1 mg/mL (3.01 mM)

Bioactivity

• Target IC50:
  AhR:21 nM
• In Vitro:
  DiMNF is a modulator that selectively acts on the aromatic hydrocarbon receptor (AHR). As a competitive AHR ligand, DiMNF has an IC50 = 21 nM and exhibits significant antagonistic activity, with DiMNF showing a unique binding mode in the ligand binding site of the AHR. DiMNF effectively inhibited cytokine-induced inflammatory gene expression at a concentration of 10 μM for 1 hour.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DiMNF, AHR, 3',4'-Dimethoxy-αNF

Compound Identifiers

PubChem CID

276138