DiMNF

SKU: orb1704573

Description

DiMNF (3',4'-Dimethoxy-αNF) is a potent and selective aryl hydrocarbon receptor (AHR) ligand. It exhibits anti-inflammatory properties by inhibiting cytokine-induced complement factor gene expression, making it a valuable tool for studying AHR-mediated immunology in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 14756-24-2
• MW: 332.4
• Purity: >98%
• Formula: C₂₁H₁₆O₄
• SMILES: O=C1C=C(OC2=C1C=CC=3C=CC=CC32)C=4C=CC(OC)=C(OC)C4
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 1.5 mg/ml)

Bioactivity

• Target IC50:
  AhR:21 nM
• In Vitro:
  DiMNF is a modulator that selectively acts on the aromatic hydrocarbon receptor (AHR). As a competitive AHR ligand, DiMNF has an IC50 = 21 nM and exhibits significant antagonistic activity, with DiMNF showing a unique binding mode in the ligand binding site of the AHR. DiMNF effectively inhibited cytokine-induced inflammatory gene expression at a concentration of 10 μM for 1 hour.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3’,4’-Dimethoxy-α-naphthoflavone

Compound Identifiers

PubChem CID

276138