Dihydrostreptomycin sulfate

SKU: orb1306092

Description

Dihydrostreptomycin sulfate is a semi-synthetic, bactericidal aminoglycoside that binds the 30S ribosomal subunit to inhibit protein synthesis. It is utilized in research applications studying tuberculosis, tularemia, and other bacterial infections, supporting both in vitro antimicrobial assays and in vivo animal model studies.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 5490-27-7
• MW: 730.71
• Purity: 99.93% (May vary between batches)
• Formula: C₂₁H₄₁N₇O₁₂·1·5H₂SO₄
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]2NC(N)=N)O[C@@H](C)[C@]1(O)CO.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]2NC(N)=N)O[C@@H](C)[C@]1(O)CO
• Target: Antibiotic,Antibacterial
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  Dihydrostreptomycin sulfate would cause cochlea damage in mouse model and cell proliferation in the spiral ligament may occur after the dihydrostreptomycin sulfate -induced damage. This process is probably related to the recovery of cochlear function.
• In Vitro:
  The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins. It enters bacterial cells by binding to a specific site on MscL(mechanosensitive channel of large conductance) and modifying its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dihydrostreptomycin, Dihydrostreptomycin sesquisulfate, Dihydrostreptomycin Sulfate, Dihydrostreptomycin sulfate, Antibiotic, Bacterial, Inhibitor, inhibit

Compound Identifiers

PubChem CID

176516788