Dihydrorotenone

SKU: orb1297393

Description

Dihydrorotenone is a potent inhibitor of mitochondrial complex I. It is widely used in research to model Parkinsonian syndrome in vitro and in vivo, facilitating studies in neurotoxicity and neurodegenerative disease mechanisms.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 6659-45-6
• MW: 396.43
• Purity: 99.58% (May vary between batches)
• Formula: C₂₃H₂₄O₆
• SMILES: [H][C@@]12COc3cc(OC)c(OC)cc3[C@]1([H])C(=O)c1ccc3O[C@H](Cc3c1O2)C(C)C
• Target: Apoptosis,Mitochondrial Metabolism,p38 MAPK
• Solubility: DMSO:27.5 mg/mL (69.37 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.05 mM)

Bioactivity

• In Vitro:
  Dihydrorotenone arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Dihydrorotenone inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, Dihydrorotenone upregulated the cell cycle repressors p21 and p53. Dihydrorotenone also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, Dihydrorotenone downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p53, MitochondrialMetabolism, Mitochondrial Metabolism, inhibit, Inhibitor, ERK, Dihydrorotenone, Apoptosis, Akt

Compound Identifiers

PubChem CID

243725