Dihydrocurcumin

SKU: orb1690893

Description

Dihydrocurcumin

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 76474-56-1
• MW: 370.4
• Purity: 97.23% (May vary between batches)
• Formula: C₂₁H₂₂O₆
• SMILES: COc1cc(CCC(=O)\C=C(/O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• Target: Fatty Acid Synthase|||PPAR
• Solubility: DMSO:22.5 mg/mL (60.75 mM)

Bioactivity

• In Vitro:
  Colon bacteria may mediate the transformation of curcumin, but this metabolism has not been well studied. Methods AND RESULTS: The metabolism of curcumin to Escherichia Ferguson (ATCC 35469) and two strains of Escherichia coli (ATCC 8739 and DH10B) was studied in modified colonic bacteria (mMCB) medium of porcine cecal fluid with or without medication. LC-MS analysis showed that after fermentation for 36 h, the conversion rate of curcumin was 16-37%, the conversion rate of demethoxycurcumin (DMC) was 6-16%, the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%, and the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%. The amount of curcumin degradation varies with different strains and medium. Three metabolites (dihydrocurcumin (DHC), tetrahydrocurcumin (THC) and ferulic acid (FA)) were identified in the fermentation culture of all strains. In addition, a compound of m/z [M-H](-) 470 was found and identified as curcumin-adduct (curcumin-L-cysteine) by precise mass FT-ICR-MS. Conclusion: This study provides a new scheme for the bacterial metabolism of curcumin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PPARα, Dihydrocurcumin, FattyAcidSynthase, Fatty Acid Synthase (FASN), Fatty Acid Synthase

Compound Identifiers

PubChem CID

5372374