Dibucaine hydrochloride

SKU: orb1224469

Description

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia.

Key Properties

• CAS Number: 61-12-1
• MW: 379.92
• Purity: >98% (HPLC)
• Formula: C₂₀H₃₀ClN₃O₂
• SMILES: O=C(C1=CC(OCCCC)=NC2=CC=CC=C12)NCCN(CC)CC.[H]Cl
• Target: AChR
• Solubility: Ethanol: 76 mg/mL (200.04 mM); Water: 76 mg/mL (200.04 mM); DMSO: 76 mg/mL (200.04 mM)

Bioactivity

• In Vitro:
  Dibucaine hydrochloride (Cinchocaine hydrochloride) reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain. Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dibucaine HCl | Dibucaine Hydrochloride | Cinchocaine hydrochloride | Cincaine chloride | Cincain

Quick Database Links

Gene Symbol

AChR