Diazoxide

SKU: orb1225191

Description

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions.(In Vitro):Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia.Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage.\n(In Vivo):Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels.Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.

Key Properties

• CAS Number: 364-98-7
• MW: 230.67
• Purity: >98% (HPLC)
• Formula: C₈H₇ClN₂O₂S
• SMILES: CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2
• Target: ATPase
• Solubility: Soluble in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 64198 | NSC 76130 | SRG 95213

Quick Database Links

Gene Symbol

ATPase