DHODH-IN-8

SKU: orb1709876

Description

DHODH-IN-8 is a potent dual inhibitor of both human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH), exhibiting antimalarial activity. It demonstrates potent inhibition with IC50 values of 0.13 µM and 47.4 µM, and Kis of 0.016 µM and 5.6 µM against the respective enzymes. This compound serves as a valuable chemical probe for researching malaria pathogenesis and DHODH-targeted therapies in both in vitro and in vivo models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1148126-03-7
• MW: 312.75
• Purity: 99.57% (May vary between batches)
• Formula: C₁₇H₁₃ClN₂O₂
• SMILES: ClC1=C(C2=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C2)C=CC=C1
• Target: DNA/RNA Synthesis,Dehydrogenase,Parasite
• Solubility: DMSO:55 mg/mL (175.86 mM)

Bioactivity

• Target IC50:
  DHODH (human):(ki)0.016 μM |DHODH (human):0.13 μM |DHODH (P. falciparum):47.4 μM |DHODH (P. falciparum):5.6 μM
• In Vitro:
  Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Plasmodium falciparum DHODH, human DHODH, DHODH, DHODH IN 8, DHODHIN8, DHODH-IN-8

Compound Identifiers

PubChem CID

54727983