DHODH-IN-4

SKU: orb1709878

Description

DHODH-IN-4 is a dual inhibitor of Plasmodium falciparum and human dihydroorotate dehydrogenase (DHODH), with IC50 values of 4 µM and 0.18 µM, respectively. This compound demonstrates antimalarial activity and serves as a valuable chemical tool for studying pyrimidine biosynthesis in parasitology and enzymology research, both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1148125-93-2
• MW: 347.2
• Purity: 98.65% (May vary between batches)
• Formula: C₁₇H₁₂Cl₂N₂O₂
• SMILES: ClC1=C(C2=CC(Cl)=C(NC(/C(=C(/C)\O)/C#N)=O)C=C2)C=CC=C1
• Target: DNA/RNA Synthesis,Parasite,Dehydrogenase
• Solubility: DMSO:55 mg/mL (158.41 mM)

Bioactivity

• Target IC50:
  DHODH (human):0.18 μM |PfDHODH:4 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHODH IN 4, DHODH, DHODHIN4, DHODH-IN-4

Compound Identifiers

PubChem CID

54727973