DHODH-IN-1

SKU: orb1709884

Description

DHODH-IN-1 is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 of 25 nM. It effectively blocks the de novo pyrimidine biosynthesis pathway and has been utilized in both cellular and animal studies to investigate its potential in oncology and immunology research.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1800296-63-2
• MW: 403.4
• Purity: 99.56% (May vary between batches)
• Formula: C₂₁H₂₀F₃N₃O₂
• SMILES: CC=1N(N=C(OC(C)C)C1OC2=C(F)C=CC=C2F)C3=C(F)C=C(C=N3)C4CC4
• Target: Dehydrogenase,DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.96 mM);DMSO:55 mg/mL (136.34 mM)

Bioactivity

• Target IC50:
  DHODH:25 nM
• In Vivo:
  The t1/2 for DHODH-IN-1 is 27–41 min.
• In Vitro:
  DHODH-IN-1 (4-100 nM) prevents the measles virus from replicating in cells. When transfecting cells with ssRNA molecules, DHODH-IN-1 (0.008-5 μM) can increase the expression of ISRE luciferase reporter gene. DHODH-IN-1 inhibits Jurkat cell proliferation with an IC50 value of 0.02 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHODHIN1, DHODH-IN-1, DHODH, DHODH IN 1

Compound Identifiers

PubChem CID

118430456