DHFR-IN-5

SKU: orb1744260

Description

DHFR-IN-5 is a potent, orally bioavailable dihydrofolate reductase (DHFR) inhibitor with a K_i of 0.54 nM against quadruple-mutant P. falciparum DHFR. This small molecule demonstrates anti-malarial efficacy in both biochemical and cellular assays, supporting its use in parasitology and antimalarial drug discovery research.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1142407-81-5
• MW: 360.41
• Formula: C₁₈H₂₄N₄O₄
• SMILES: O(CCCOC1=C(CCC(O)=O)C=CC=C1)C=2C(CC)=NC(N)=NC2N
• Target: Others,DHFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

66563688