DG051

SKU: orb1296245

Description

DG051 is a potent and selective small molecule inhibitor of leukotriene A4 hydrolase (LTA4H), exhibiting an IC50 of 47 nM. It serves as a valuable research tool for investigating the role of LTB4 in inflammation, enabling both in vitro biochemical assays and in vivo models of inflammatory diseases.

Research Area

Metabolism Research

Key Properties

• CAS Number: 929915-58-2
• MW: 426.33
• Purity: 98.26%
• Formula: C₂₁H₂₅Cl₂NO₄
• SMILES: Cl.OC(=O)CCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1
• Target: Aminopeptidase
• Solubility: DMSO:317 mg/mL (743.56 mM)

Bioactivity

• Target IC50:
  LTA4H:47 nM (IC50)
• In Vitro:
  DG051 is a potent LTA4H aminopeptidase inhibitor against L-alanine p-nitroanilide (IC50: 72 nM) and suppresses human whole blood (HWB) with an IC50 of 37 nM . DG051 is currently in Phase II clinical development for preventing heart attacks as an LTA4H inhibitor .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DG051, DG-051, DG 051, Aminopeptidase, inhibit, LTA4H, Inhibitor

Compound Identifiers

PubChem CID

44818987