Denzimol

SKU: orb1819181

Description

Denzimol is a novel small molecule anticonvulsant agent with selectivity for the suppression of tonic seizure activity. It is a useful research tool for investigating seizure mechanisms in both in vitro electrophysiology studies and in vivo animal models of epilepsy.

Key Properties

• CAS Number: 73931-96-1
• MW: 292.37
• Purity: 99.98%
• Formula: C₁₉H₂₀N₂O
• SMILES: C(CN1C=CN=C1)(O)C2=CC=C(CCC3=CC=CC=C3)C=C2
• Target: Others
• Solubility: DMSO:16.67 mg/mL (57.02 mM)

Bioactivity

• In Vivo:
  Denzimol (30 mg/kg; p.o.; 14 days; mice) reduced brain concentration and anticonvulsant activity compared with non-treated mice, and t1/2 beta was significantly changed from 2.10 to 1.53 hr. Tonic hindlimb extension was completely abolished at a brain denzimol concentration higher than 15 mcg/g, whereas the minimum effective brain concentration was between 2-3 mcg/g both in acute and repeatedly treated animals. The brain concentration of denzimol is closely correlated with its anticonvulsant effect both in acute and repeatedly treated animals. Furthermore, these findings seem to suggest that the decreased anticonvulsant activity of denzimol, following repeated administrations, might be due to a development of pharmacokinetic tolerance.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

53626