Dehydronitrosonisoldipine

SKU: orb1309777

Description

Dehydronitrosonisoldipine is a SARM1 inhibitor used in neurodegenerative disease research. It has been shown to protect against axon degeneration and inhibit vincristine-induced cADPR production in neuronal studies, supporting its application in both in vitro and in vivo models of neuroprotection.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87375-91-5
• MW: 370.4
• Purity: 99.68%
• Formula: C₂₀H₂₂N₂O₅
• SMILES: COC(=O)c1c(C)nc(C)c(C(=O)OCC(C)C)c1-c1ccccc1N=O
• Target: Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.75 mM);DMSO:90 mg/mL (242.98 mM)

Bioactivity

• In Vitro:
  Dehydronitrosonisoldipine exhibits an IC50 of 4 μM in the sterile α and TIR motif-containing 1-dN-expression cells, and decreases the cellular cADPR.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, Dehydronitrosonisoldipine, Calcium channel, Calcium Channel

Compound Identifiers

PubChem CID

14823523