Deferiprone

SKU: orb1308158

Description

Deferiprone

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 30652-11-0
• MW: 139.15
• Purity: 99.71%
• Formula: C₇H₉NO₂
• SMILES: OC1=C(C)N(C)C=CC1=O
• Target: HCV Protease,Ferroptosis,Apoptosis,UGT,COX
• Solubility: DMSO:2.17 mg/mL (15.59 mM);H2O:8.06 mg/mL (57.92 mM)

Bioactivity

• In Vivo:
  Administration of 100 mg/kg Deferiprone resulted in a 24% reduction in the average cross-sectional area o the basilar artery in rabbits. When combined with subarachnoid hemorrhage (SAH), Deferiprone also demonstrated variability in the waviness o the internal elastic lamina in rabbits.
• In Vitro:
  At a concentration of 1 mM Deferiprone causes a significant decrease in complex I-III activity in iron-overloaded cardiomyocytes. It exhibits cytotoxic effects on human tumor cell lines HSC-2, HSC-3, and HL-60, with IC50 Values of 13.5 μg/ml, 9.9 μg/ml, and 10.6 μg/ml, respectively the cytotoxicity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. At 100 μg/ml, Deferiprone induces inter-nucleosomal DNA fragmentation in HL-60 cells, a process inhibited b the addition of FeCl3. Protection of myocytes from doxorubicin-induced lactate dehydrogenase release is observed with 100 μM Deferiprone. It effectively inhibit the transfer of radiolabeled iron from iron-loaded cardiomyocytes and protects or restores mitochondrial respiratory enzyme activity in a xanthine oxidase/hypoxanthine superoxide generating system at a concentration of 0.3 mM. furthermore , 0.5 mM Deferiprone enhance the clearance of free iron from RBC membranes in a time- and dose-dependent manner. A 3 mM concentration significantly reduces hydroxyl radical production fro the iron(III)-adriamycin complex in the xanthine oxidase/hypoxanthine superoxide generating system.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP 20, CP20, CP-20, Deferidone, Deferiprone, Ferroptosis, Inhibitor, HCV, HCV Protease, HCVProtease, Hepatitis C virus, inhibit, iron, UGT1-6

Compound Identifiers

PubChem CID

2972