Deferiprone

SKU: orb1308158

Description

Deferiprone is a small molecule iron chelator used in research to study iron overload. It is applied in both in vitro and in vivo models to investigate conditions like thalassemia and hemochromatosis, facilitating the study of iron metabolism and chelation therapy.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 30652-11-0
• MW: 139.2
• Purity: >98%
• Formula: C₇H₉NO₂
• SMILES: OC1=C(C)N(C)C=CC1=O
• Target: Chelator
• Solubility: Soluble in water (up to 5 mg/ml with warming)

Bioactivity

• In Vivo:
  Administration of 100 mg/kg Deferiprone resulted in a 24% reduction in the average cross-sectional area of the basilar artery in rabbits. When combined with subarachnoid hemorrhage (SAH), Deferiprone also demonstrated variability in the waviness of the internal elastic lamina in rabbits.
• In Vitro:
  At a concentration of 1 mM, Deferiprone causes a significant decrease in complex I-III activity in iron-overloaded cardiomyocytes. It exhibits cytotoxic effects on human tumor cell lines HSC-2, HSC-3, and HL-60, with IC50 values of 13.5 μg/mL, 9.9 μg/mL, and 10.6 μg/mL, respectively. The cytotoxicity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. At 100 μg/mL, Deferiprone induces inter-nucleosomal DNA fragmentation in HL-60 cells, a process inhibited by the addition of FeCl3. Protection of myocytes from doxorubicin-induced lactate dehydrogenase release is observed with 100 μM Deferiprone. It effectively inhibits the transfer of radiolabeled iron from iron-loaded cardiomyocytes and protects or restores mitochondrial respiratory enzyme activity in a xanthine oxidase/hypoxanthine superoxide generating system at a concentration of 0.3 mM. Furthermore, 0.5 mM Deferiprone enhances the clearance of free iron from RBC membranes in a time- and dose-dependent manner. A 3 mM concentration significantly reduces hydroxyl radical production from the iron(III)-adriamycin complex in the xanthine oxidase/hypoxanthine superoxide generating system.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP 37,391; DN 18001AF

Compound Identifiers

PubChem CID

2972