Deferasirox (Fe3+ chelate)

SKU: orb1707994

Description

Deferasirox is an orally active iron chelator used to study iron overload. Its ability to chelate Fe3+ and inhibit the anti-apoptotic protein MCL-1 also supports research into its potential anticancer mechanisms, as investigated in both cellular and animal models.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 554435-83-5
• MW: 426.18
• Purity: ≥98.0% (May vary between batches)
• Formula: C₂₁H₁₂FeN₃O₄
• SMILES: O=C([O-])C1=CC=C(C=C1)N2N=C3C=4C=CC=CC4[O-][Fe+3]5[O-]C=6C=CC=CC6C2=[N]35
• Target: Ferroptosis,Apoptosis,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.69 mM);DMSO:30 mg/mL (70.39 mM)

Bioactivity

• In Vitro:
  Deferasirox (Fe3+ chelate) promotes cell cycle arrest in cervical cancer cell lines by regulating the expression of cell cycle regulatory factors cyclin D1, cyclin E, and proliferating cell nuclear antigen (PCNA).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deferasirox, Deferasirox (Fe3+ chelate), Deferasirox (Fe-3+ chelate), Apoptosis, Fe3+ chelate

Compound Identifiers

PubChem CID

71576680