Debio 0617B

SKU: orb1685929

Description

Debio 0617B is a multi-kinase inhibitor targeting JAK, ABL, SRC, and class III/V RTKs upstream of STAT3/STAT5. It impairs maintenance and self-renewal of human AML stem/progenitor cells in vitro and is a research tool for studying STAT3-driven malignancies, including solid tumors, in preclinical models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1332329-27-7
• MW: 581.98
• Formula: C₂₈H₂₃ClF₃N₇O₂
• SMILES: ClC=1C(N2CC=3C(CC2)=NC(NC4=CC=C(C(NC)=O)C=C4)=NC3)=CC(NC(=O)C5=CC(C(F)(F)F)=CC=N5)=CC1
• Target: JAK,Others,STAT,Bcr-Abl

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

67328148