DDD85646

SKU: orb1305126

Description

DDD85646 is a potent and selective inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT), exhibiting sub-nanomolar binding affinity (Ki=1.44 nM) and potent activity against the parasite (EC50=2 nM). It shows selectivity over human NMT (IC50=4 nM), making it a valuable chemical probe for studying trypanosomatid biology and for anti-parasitic drug discovery research in both in vitro and in vivo models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 1215010-55-1
• MW: 495.43
• Purity: 99.76% (May vary between batches)
• Formula: C₂₁H₂₄Cl₂N₆O₂S
• SMILES: Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
• Target: Parasite
• Solubility: DMSO:95 mg/mL (191.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.66 mM)

Bioactivity

• Target IC50:
  NMT:1.44 nM(Ki, T. brucei)|NMT:2 nM(EC50, T. brucei)|NMT:2 nM(T. brucei)|NMT:4 nM(human)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA/RNA Synthesis, African trypanosomiasis, inhibit, Parasite, NMT, N-myristoyltransferase, N-myristoyltransferase-1 (NMT-1), Inhibitor, DDD85646, DDD-85646, DDD 85646, trypanosoma brucei

Compound Identifiers

PubChem CID

44199337