dCeMM2

SKU: orb1688559

Description

dCeMM2 is a molecular glue degrader that induces the interaction of CDK12-cyclin K with the CRL4B E3 ligase, resulting in the ubiquitination and proteasomal degradation of cyclin K. This mechanism enables the study of transcription and DNA damage response pathways in both cellular and in vivo research models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 296771-07-8
• MW: 370.82
• Purity: 99.68% (May vary between batches)
• Formula: C₁₆H₁₁ClN₆OS
• SMILES: Clc1ccc(NC(=O)CSc2nnc3c(n2)[nH]c2ccccc32)nc1
• Target: CDK,Molecular Glues,PROTACs
• Solubility: DMSO:16.7 mg/mL (45.04 mM);10% DMSO+90% Corn Oil:1.5 mg/mL (4.05 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MolecularGlues, Molecular Glues

Compound Identifiers

PubChem CID

5286209