dCeMM1

SKU: orb1685577

Description

dCeMM1 is a molecular glue degrader that induces the CRL4DCAF15 E3 ligase to target and degrade the RNA-binding protein RBM39, as demonstrated by reduced RBM39 levels in WT KBM7 cells. This tool compound is used in vitro to study targeted protein degradation, splicing regulation, and cancer biology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 118719-16-7
• MW: 369.23
• Purity: 99.29% (May vary between batches)
• Formula: C₁₄H₁₃BrN₂O₃S
• SMILES: Cc1ccc(cc1)S(=O)(=O)NN=Cc1cc(Br)ccc1O
• Target: Molecular Glues,PROTACs
• Solubility: DMSO:1.8 mg/mL (4.88 mM)

Bioactivity

• In Vitro:
  dCeMM1 (0-100 µM; 3 days) inhibited cell growth with EC50 values of 3 and 8 µ M for WT and UBE2Mmut KBM7 cells, respectively, and at 10 µ M for 12-16 hours, it reduced RBM39 expression in WT KBM7 cells .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Molecular Glues, MolecularGlues, dCeMM1

Compound Identifiers

PubChem CID

1368364