DB1255 2TFA

SKU: orb2569957

Description

DB1255 2TFA is a potent small molecule inhibitor that selectively binds the minor groove to disrupt ERG-DNA interactions. It is a valuable research tool for studying ERG-driven genetic disorders and cancers, enabling mechanistic investigations in both in vitro biochemical assays and in vivo model systems.

Research Area

Molecular Biology

Key Properties

• MW: 630.58
• Purity: 98.32% (May vary between batches)
• Formula: C₂₆H₂₀F₆N₄O₄S₂
• SMILES: O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.N=C(C1=CC=C(C2=CC=C(C3=CC=C(C4=CC=C(C(N)=N)C=C4)S3)S2)C=C1)N
• Target: DNA

Bioactivity

• In Vitro:
  DNase I footprinting, biosensor surface plasmon resonance, and circular dichroism experiments show that DB1255 2TFA has an unusual and strong monomer binding mode in minor groove sites that contain a single GC base pair flanked by AT base pairs.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERG/DNA binding, DB1255 2TFA(915978-94-8 Free base), DB12552TFA(915978948Freebase)

Compound Identifiers

PubChem CID

172652777