Darunavir

SKU: orb1305688

Description

Darunavir (TMC114) is a potent HIV-1 protease inhibitor used in antiretroviral therapy. To combat resistance, it is co-administered with other antiretroviral agents. It is widely used in research for studying viral replication, drug resistance mechanisms, and efficacy in both cellular and animal models of HIV infection.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 206361-99-1
• MW: 547.66
• Purity: 99.83% (May vary between batches)
• Formula: C₂₇H₃₇N₃O₇S
• SMILES: O(C(N[C@H]([C@@H](CN(S(=O)(=O)C1=CC=C(N)C=C1)CC(C)C)O)CC2=CC=CC=C2)=O)[C@@H]3[C@]4([C@@](OC3)(OCC4)[H])[H]
• Target: HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.65 mM);Ethanol:35 mg/mL (63.91 mM)

Bioactivity

• In Vivo:
  Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TMC114, TMC-114, TMC 114, UIC 94017, UIC94017, UIC-94017, Minimal, inhibit, Inhibitor, HIV Protease, HIVProtease, HIV, Human immunodeficiency virus, AID, cytotoxicity, Darunavir

Compound Identifiers

PubChem CID

213039