Daptomycin

SKU: orb1307844

Description

Daptomycin (LY146032) is a cyclic lipopeptide antibiotic with potent activity against Gram-positive bacteria. It is widely used in research for both in vitro susceptibility testing and in vivo models of infections, such as those caused by Staphylococcus aureus and Enterococcus species.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 103060-53-3
• MW: 1620.71
• Purity: >92%
• Formula: C₇₂H₁₀₁N₁₇O₂₆
• SMILES: CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](CC(=O)c2ccccc2N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC1=O)[C@H](C)CC(O)=O
• Target: Antibiotic
• Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 50 mg/ml).

Bioactivity

• In Vivo:
  Administering daptomycin at a dosage of 10 mg/kg twice daily significantly reduced the amount of organisms per kidney compared to infected untreated controls within 48 hours of treatment initiation. Although a 20 mg/kg dose administered once daily is less effective, it still significantly lowers colony counts after 4 days of therapy, with its efficacy being comparable to that of vancomycin or vancomycin-gentamicin administered twice daily.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cubicin; LY146032

Compound Identifiers

PubChem CID

16134395