Danirixin

SKU: orb1223528

Description

Danirixin (GSK-1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8); blocks the CD11b upregulation with pIC50 of 6.05 and 6.3, respectively, in rat and human whole-blood studies; blocks the influx of neutrophils into the lung in vivo in rats following aerosol lipopolysaccharide (ED50=1.4 mg/kg); orally active.COPD Phase 2 Clinical(In Vitro):Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.

Key Properties

• CAS Number: 954126-98-8
• MW: 441.9041
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁ClFN₃O₄S
• SMILES: ClC(C(S([C@H]1CCCNC1)(=O)=O)=C2O)=CC=C2NC(NC3=CC=CC(F)=C3C)=O
• Target: Chemokine Receptor
• Solubility: DMSO: 8 mg/mL

Bioactivity

• In Vitro:
  Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK-1325756

Quick Database Links

Gene Symbol

Chemokine Receptor