Daltroban

SKU: orb1707400

Description

Daltroban (SKF 96148) is a selective thromboxane A2 receptor antagonist. It has demonstrated protective effects against reperfusion injury in research models and is known to elevate intracellular calcium levels in vascular smooth muscle cells in vitro, supporting its study in cardiovascular pharmacology.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 79094-20-5
• MW: 353.82
• Purity: 99.49% (May vary between batches)
• Formula: C₁₆H₁₆ClNO₄S
• SMILES: OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
• Target: Prostaglandin Receptor,PPAR
• Solubility: DMSO:50 mg/mL (141.31 mM)

Bioactivity

• In Vivo:
  Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion, in comparison with vehicle (physiological saline)-treated cats. Daltroban (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Daltroban, BM 13505, BM13505, BM-13505, TXA2, TXA2R, SKF96148, SKF-96148, SKF 96148

Compound Identifiers

PubChem CID

54343